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General and abdominal obesity and incident asthma in adults: The hunt study.

Eur Respir J. 2012 May 31. Brumpton B, Langhammer A, Romundstad P, Chen Y, Mai XM. Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

Measures of body mass index (BMI) and waist circumference (WC) define general obesity and abdominal obesity respectively. While high BMI has been established as a risk factor for asthma in adults, WC has seldom been investigated.To determine the association between BMI, WC, and incident asthma in adults, we conducted a prospective study (n=23 245) in a population living in Nord-Trøndelag, Norway in 1995-2008.Baseline BMI and WC were measured and categorised as general obesity (BMI ≥30.0 kg·m(-2)) and abdominal obesity (WC ≥88 cm in females and ≥102 cm in males). Incident asthma was self-reported new-onset cases during an 11-year follow-up period. Odds ratios (ORs) for asthma associated with obesity were calculated using multivariable logistic regression.General obesity was a risk factor for asthma in females (OR 1.96, 95% confidence interval (CI) 1.52-2.52) and males (OR 1.84, 95% CI 1.30-2.59). In females, after additional adjustment for BMI, abdominal obesity remained a risk factor for asthma development (OR 1.46, 95% CI 1.04-2.05).

Abdominal obesity seems to increase the risk of incident asthma in females additionally to BMI, indicating that using both measures of BMI and WC in females may be a superior clinical assessment for asthma risk than any measure alone.

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